XB-FEAT-993074: Difference between revisions
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XB-GENE-993075 was previously associated with GeneID:100145402, which was withdrawn because it | XB-GENE-993075 was previously associated with GeneID:100145402, which was withdrawn because it | ||
was based on a zebrafish transcript (BC160969.1) that was | was based on a zebrafish transcript (BC160969.1) that was erroneouslyannotated as Xenopus tropicalis. | ||
He moved XB-GENE-993075 and the official nomenclature (selenow, selenoprotein W) to GeneID:100485593, which now represents Xt selenow gene. | |||
While reviewing this locus, he found another paralog of selenow (GeneID:101731107) on chromosome 3, which is restricted to fish and frog (PMID:22479358). | |||
This locus needs official nomenclature. | This locus needs official nomenclature. | ||
To comply with Gladyshev et al.'s recommendation for naming paralogs | To comply with Gladyshev et al.'s recommendation for naming paralogs withsuffixes on the symbols (PMID:27645994, Table 3), he suggested the | ||
following nomenclature for the 2 paralogs: | following nomenclature for the 2 paralogs: | ||
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selenow (XB-GENE-993075) > selenow1 selenoprotein W1 | selenow (XB-GENE-993075) > selenow1 selenoprotein W1 | ||
GeneID:101731107 > | new gene GeneID:101731107 > selenow2 selenoprotein W2 | ||
ACTION BY XENBASE: 09/12/17 | ACTION BY XENBASE: 09/12/17 | ||
CHANGED SELENOW TO SELENOW1 AS REQUESTED | CHANGED SELENOW TO SELENOW1 AS REQUESTED | ||
SUBMIT SELENOW2 DATA FOR REQUEST NEW GENE PAGE | SUBMIT SELENOW2 DATA FOR REQUEST NEW GENE PAGE | ||
=NCBI summary= | |||
Summary | |||
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain in mammals. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A paralog of this gene is found on chromosome 3 (GeneID:101731107). [provided by RefSeq, Aug 2017] | |||
Revision as of 11:58, 21 November 2017
selenow
This is the community wiki page for the gene selenow please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
11/07/2016 Human symbol has changed for genepage ID: 993074 From sepw1 to SELENOW
Human symbol has changed for Entrez Gene: 6415. From SEPW1 to SELENOW
Human name has changed for Entrez Gene: 6415. From selenoprotein W, 1 to selenoprotein W
Mouse symbol has changed for Entrez Gene: 20364. From Sepw1 to Selenow
09/12/2017 correspondance from Bhanu Rajput, Ph. D. Staff Scientist Reference Sequence Project NCBI/NLM/NIH 2. ... issue concerning selenow gene.
XB-GENE-993075 was previously associated with GeneID:100145402, which was withdrawn because it was based on a zebrafish transcript (BC160969.1) that was erroneouslyannotated as Xenopus tropicalis.
He moved XB-GENE-993075 and the official nomenclature (selenow, selenoprotein W) to GeneID:100485593, which now represents Xt selenow gene.
While reviewing this locus, he found another paralog of selenow (GeneID:101731107) on chromosome 3, which is restricted to fish and frog (PMID:22479358). This locus needs official nomenclature.
To comply with Gladyshev et al.'s recommendation for naming paralogs withsuffixes on the symbols (PMID:27645994, Table 3), he suggested the following nomenclature for the 2 paralogs:
current symbol name
selenow (XB-GENE-993075) > selenow1 selenoprotein W1
new gene GeneID:101731107 > selenow2 selenoprotein W2
ACTION BY XENBASE: 09/12/17 CHANGED SELENOW TO SELENOW1 AS REQUESTED SUBMIT SELENOW2 DATA FOR REQUEST NEW GENE PAGE
NCBI summary
Summary This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain in mammals. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A paralog of this gene is found on chromosome 3 (GeneID:101731107). [provided by RefSeq, Aug 2017]