XB-FEAT-995844

insc

This is the community wiki page for the gene insc please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

05/29/2017

Human name has changed for Entrez Gene: 387755. From inscuteable homolog (Drosophila) to INSC, spindle orientation adaptor protein.

summary

In Drosophila, neuroblasts divide asymmetrically into another neuroblast at the apical side and a smaller ganglion mother cell on the basal side. Cell polarization is precisely regulated by 2 apically localized multiprotein signaling complexes that are tethered by Inscuteable, which regulates their apical localization (Izaki et al., 2006 [PubMed 16458856]).[supplied by OMIM, Mar 2008]