Y27632: Difference between revisions

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imported>Kevin
(Created page with "==Description== [[File:______|frame|right|_______ structure, photo from Sigma-Aldrich]] ==Genes Affected== ==Suppliers== *[http://www.xenbase.org/entry/ SORRYONLYALINKTOXENB...")
 
imported>Kevin
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==Description==
==Description==
[[File:______|frame|right|_______ structure, photo from Sigma-Aldrich]]
"Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP."
*-Sigma Product Description
[[File:Y27632.png|frame|right|Y27632 structure, photo from Sigma-Aldrich]]


==Genes Affected==
==Genes Affected==
 
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=984660 rock1]
*[http://www.xenbase.org/gene/showgene.do?method=display&geneId=959450 rock2]
==Suppliers==
==Suppliers==
*[http://www.xenbase.org/entry/ SORRYONLYALINKTOXENBASE]
*[http://www.sigmaaldrich.com/catalog/product/sigma/y0503?lang=en&region=US Sigma]
*[http://www.tocris.com/dispprod.php?ItemId=1382#.VZWg2RtVhBc Tocris]


==Usage Notes==
==Usage Notes==
 
10uM in culture
==References==
==References==
*[https://pubchem.ncbi.nlm.nih.gov/ Pubchem]
*[https://pubchem.ncbi.nlm.nih.gov/compound/448042 Pubchem]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=__________ ____ et al., 2xxxx]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=44762 Langdon et al., 2012]


>___ Xenbase articles contain a reference to _____ according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
>28 Xenbase articles contain a reference to Y27632 or Y-27632 according to [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso]
*
*
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]]

Revision as of 14:51, 2 July 2015

Description

"Y-27632 is highly potent, cell-permeable, selective ROCK (Rho-associated coiled coil forming protein serine/threonine kinase) inhibitor. Ki = 140 nM for p160ROCK. Y-27632 also inhibits ROCK-II with equal potency. The inhibition is competitive with respect to ATP."

  • -Sigma Product Description
Y27632 structure, photo from Sigma-Aldrich

Genes Affected

Suppliers

Usage Notes

10uM in culture

References

>28 Xenbase articles contain a reference to Y27632 or Y-27632 according to textpresso