XB-FEAT-17329844

prss57l

This is the community wiki page for the gene prss57l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

26APRIL2023

Xenopus gene symbol and name changed from XB17329844 [provisional] to prss57, serine protease 57

1JUNE2023

Xenopus gene symbol and name changed from prss57, serine protease 57 TO prss57l, serine protease 57 like

orthology

DIOPT/EggNog homology group matches: Xlaevis : XP_041417826.1 and Xtrop XP_002937430.1 give the same results:

• 113proteins/93 species of PRSS57 PROTEINS/GENE HOMOLOGY GROUP ( best match)

• >1800 PROTEINS/247 species from fungi to worms to vertebrates (birds reptile fish mammals) of other PRSS## genes, ( eg prss22, 27, 48 45 55 8 21 12 54 56 53 33 ) including 127 sequences from Xenopus/Silurana, prss8,57 tmprss6,2 ( 2nd best match)

• 3rd best match is to KLK7 genes in 89 spp.

synteny

Xtrop.Chr1: misp< palm< XB17329844(prss57l)> LOC105945763(prkcd)< pgpep1< timm10>

Xlaevis.Chr1L: LOC108712598(misp)< palm.L< XB17329844(prss57l)> LOC108712617(pgpep1)< timm10>

Xla.Chr1S: LOC108706851(misp)< palm.S< pgpep1.S< timm10.S>

looking for conserved flanking genes in human:

Human chr19: PALM> MISP> PTBP1> PLPPR3< AZU1> PRTN3> ELANE>

Human chr19: PDE4C< IQCN< JUNO LSM4< PGPEP1> GDF15 LRRC25< SSBP4> ISYNA1

Human CHR11: SLC43A3< RTN4RL2> SLC43A1< TIMM10< SMTNL1> UBE2L6< SERPING1> YPEL4<

Conclusions from orthology and synteny analaysis:

• NO v10 Xalevis.S model for prss57
• This gene is also on Chr1, but is not a tandem duplication , so doesn’t get .2
• SYNTENY NOT CONSERVED WITH HUMAN- DOESN’T HELP US ID/NAME the GENE
• We will call this gene a 'prss57-like gene.'
• no orthologs currently assignable

proteins for prss57l genes

Xtrop protein:

serine protease 57 [Xenopus tropicalis]

NCBI Reference Sequence: XP_002937430.1

>XP_002937430.1 serine protease 57 [Xenopus tropicalis] MMMHLVLLTAALFSLPSSETYRIVGGHEAKPHSRPYMVSLQRQDKSHFCGGTLIHPKWVLTAAHCQEGWS MDLTRVVLGAHWLYWSDRPVQVFRTLKFVQHPQFNPQTFQSDLLLLKLNDSVHFSPAVRTIPLPAPNTDV IPGTACSVAGWGLTSDSGTRPFALMEADVDVISRMSCNKTWLGGIDESMLCTATPGAPFKGFCDGDSGGP LVCGDRVEGVVSFSGSYCGDPHTPDVYTRVTSFLDWIQETISEF

X.laevis.L protein:

serine protease 57 isoform X2 [Xenopus laevis]

NCBI Reference Sequence: XP_041417826.1

>XP_041417826.1 serine protease 57 isoform X2 [Xenopus laevis] MVSLQTPFQSHFCGGTLIHPKWVLTAAHCQEVGSLDVTRVVLGAHRLHLPDRSVQVFSTLKSVQHPEYNP QTFQSDILLLKLNGSAKINPAVRTLPLPVPNTDVIPGTSCSVAGWGSTFNARSKFFPLMETDVDIVNRKD CNITWLGGISESMLCTATPGAPFKGFCDGDSGGPLVCRGRVEGVVSFSGQYCGDPRTPDVYTRVTSFLDW IQKTISTF