XB-FEAT-29077362

plekhg4bl

This is the community wiki page for the gene plekhg4bl please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature updates

27MAY2025

Xenopus gene name & symbol was changed from KIAA1755, KIAA1755 ortholog to plekhg4bl, pleckstrin homology and RhoGEF domain containing G4B like. This is based on the X.alevis S protein which was characterized as a "pleckstrin homology and RhoGEF domain containing G4B like", and the gene symbol in human with the same root name.

THis decision is supported by synteny, in that all 3 Xenopus models are syntenic; and protein similarity. Below is the X. trop v X. laevis.S proteins alignment stats (using EMBOSS WATER PSA) .

Aligned_sequences: 2

1: XP_002932909.3

2: XP_041434449.1

Matrix: EBLOSUM62

Gap_penalty: 10.0

Extend_penalty: 0.5

Length: 1538

Identity: 1373/1538 (89.3%)

Similarity: 1424/1538 (92.6%)

Gaps: 39/1538 ( 2.5%)

Score: 7111.5