XB-FEAT-29078818

ovos5a

This is the Xenbase community page for Xenopus ovos5a. Please feel free to record here anything relevant to these genes/proteins that is not found elsewhere on Xenbase.

nomenclature updates

18DEC2025

Xenopus Gene Name and symbol was changed from LOC100487580 , LOC108695710 and LOC108697150, ovostatin, to ovos5a, ovostatin 5A following phylogenetic analaysis of the vertebrate ovostatin and a2m protein/gene family by the HGNC.

LOC100487580 , LOC108695710 , LOC108697150, are recorded as Synonyms.

OVOS protein background

Ovostatins (OVOS gene /protein family) were originally called “ovomacroglobulins”, and were first identified in the 1960's as an abundant proteins from the 'whites' of chicken eggs [1]. Ovostatins were subsequently shown to be active enzymes that inhibited the peptidases trypsin, papain and thermolysin [2].

References: 1. Miller et al 1966. Biochemistry. 1966;5:952–8. 2. Nielsen et al 1994. DNA Seq. 1994;5:111–9