XB-FEAT-29079474

ovos5c

This is the Xenbase community page for Xenopus ovos5c. Please feel free to record here anything relevant to these genes/proteins that is not found elsewhere on Xenbase.

nomenclature updates

18DEC2025 Xenopus Gene Symbol nad gene names were changed from LOC100488897 ovostatin, , LOC108695708, alpha-2-macroglobulin, and LOC100036845, ovostatin-like precursor to ovos5c/5c.L/5c.S, ovostatin 5C/L/S homeolog following phylogenetic analysis of the vertebrate ovostatin and A2M protein/gene family by Xenbase and the HGNC.

LOC100488897, LOC108695708, LOC100036845 are recorded as Synonyms.

OVOS protein background

Ovostatins (OVOS gene /protein family) were originally called “ovomacroglobulins”, and were first identified in the 1960's as an abundant proteins from the 'whites' of chicken eggs [1]. Ovostatins were subsequently shown to be active enzymes that inhibited the peptidases trypsin, papain and thermolysin [2].

References: 1. Miller et al 1966. Biochemistry. 1966;5:952–8. 2. Nielsen et al 1994. DNA Seq. 1994;5:111–9