XB-FEAT-29080646

ovos5f

This is the community wiki page for the gene ovos5f please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature updates

23OCT2025

Xenopus gene nomenclature was updated, changing from LOC100491357, ovostatin-like to ovos5f, ovostatin 5f, following phylogenetic review of the A2M and OVOS gene families by Xenbase curators and the HGNC.

OVOS protein background

Ovostatins (OVOS gene /protein family) were originally called “ovomacroglobulins”, and were first identified in the 1960's as an abundant proteins from the 'whites' of chicken eggs [1]. Ovostatins were subsequently shown to be active enzymes that inhibited the peptidases trypsin, papain and thermolysin [2].

References: 1. Miller etal 1966. Biochemistry. 1966;5:952–8. 2. Nielsen et al 1994. DNA Seq. 1994;5:111–9