XB-FEAT-5751720

pttg1lp2

This is the community wiki page for the gene pttg1lp2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature update

03.24.2020

Following discussion with HGNC and NCBI RefSeq, name change from and 'unnamed' PTTG1IP-like gene to "PTTG1IP family member 2", gene symbol "PTTG1IP2" in human. In Xenopus therefore, "PTTG1IP family member 2", gene symbol "pttg1lp2"

background to name change:reported by David Webbat NCBI refSeq.

Key: RSCOM-45 URL: https://ncbijira.ncbi.nlm.nih.gov/browse/RSCOM-45

Components: chicken, Ensembl, human, mouse, rat, vgnc, xenopus, zebrafish

Reporter: David Webb

Assignee: Elspeth Bruford

Hi HGNC, I'd like your input on a PTTG1IP-like gene that is inconsistently annotated and named.

The paralogous gene, PTTG1IP, is consistently found upstream of the SUMO3 gene in Osteichthyes and a PTTG1IP-like gene is consistently found upstream of the CDK14 gene in Osteichthyes.

However, in mammals this PTTG1IP-like gene is sometimes unannotated or is annotated as non-coding or as protein coding.

I'm confident this PTTG1IP-like gene is protein coding throughout Osteichthyes. So, I'd like your input on what it should be named (pituitary tumor-transforming gene 1 protein-interacting protein probably isn't appropriate).

I'd appreciate it if the curators at MGI, RGD, and Ensembl could look at this PTTG1IP-like gene and confirm that it's protein coding. -DW

Gene IDs effected:

human (GeneID: 102723899)

mouse (MGI:2686532; GeneID: 381716)

rat (RGD:9118001; GeneID: 103692048)

chicken (GeneID: 420545)

X.tropicalis (XB-GENEPAGE-5751720; GeneID: 496874)

zebrafish (GeneID: 101886260)

4.30.2020 HGNC, ZFIN, and NCBI agree that this gene should be called PTTG1IP2 and "PTTG1IP family member 2".

The following gene/species can have their official symbol updated to PTTG1IP2: human (GeneID: 102723899) mouse (MGI:2686532; GeneID: 381716) rat (RGD:9118001; GeneID: 103692048) chicken (GeneID: 420545) X.tropicalis (XB-GENEPAGE-5751720; GeneID: 496874) zebrafish (GeneID: 101886260)

15June 2020 Human symbol has changed for genepage ID: 5751720 From pttg1ip2 to LOC102723899, Xenopus name will remain unchanged, KEEPING THE AGREED UPON NAME, PTTG1IP family member 2.

NOTES ON SYNTENY

amniotes CLDN12>...PTTG1IP2>...CDK14>...FZD1>

amphibians SRI>...DUS3L<...PTTG1IP2>...CDK14>

gar, reedfish, and thorny skate SRI>...DUS3L<...PTTG1IP2>...CDK14>...FZD1>

zebrafish and pike PTTG1IP2>...CDK14>...FZD1>