XB-FEAT-5795058

vma22

This is the community wiki page for the gene vma22, please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

24APRIL2023

Xenopus gene name updated from XB5795058 to ccdc115

Approved by HGNC 2025-02-07

Human and Xenopus gene name has changed from CCDC115, coiled-coil domain containing 115 to vma22, vacuolar ATPase assembly factor VMA22.

Summary for human VMA 22 from NCBI

The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) vesicles in some human cells. The encoded protein shares some homology with the yeast V-ATPase assembly factor Vma22p, and the orthologous protein in mouse promotes cell proliferation and suppresses cell death. Defects in this gene are a cause of congenital disorder of glycosylation, type IIo in humans. [provided by RefSeq, Mar 2016]

summary for Xenopus vma22

Predicted to act upstream of or within vacuolar proton-transporting V-type ATPase complex assembly. Predicted to be located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum-Golgi intermediate compartment; and lysosome. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIo. Orthologous to human VMA22, vacuolar ATPase assembly factor VMA22 [aka, CCDC115 (coiled-coil domain containing 115]. [provided by Alliance of Genome Resources, Jun 2025]