XB-FEAT-5832502
gsg1l2l
This is the community wiki page for the gene gsg1l2l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
2020/06/04 Human symbol has changed for genepage ID: 5832502 From gsg1lr to gsg1l
10.26.2020
this gene may or may not be the true orthologue of the human gene, so is currently assigned a 'like' designation. This issue is currently under review by Xenbase curators.
24.04.2023
NCBI recognizes X. tropicalis gsg1l (309aa ) as the true ortholog of human GSG1L (331aa), and this is supported by protein architecture, and synteny as the upstream flanking genes are conserved x-species.
HumanChr16: GTF3C1 ... KATNIP> ...GSG1L ... TPRKBP2 ... XPO6
XtropChr9: gtf3c1 ... katnip .. gsg1l ... alg1 ... eef2kmt ..
17Apr2026
Xenopus genes on XB-GENEPAGE-5832502 have been renamed following study by the NCBI refSeq team, as synteny and BLASTp recognize similar genes on chr9/9L as the true gsg1l orthologs.
The correct symbol for the genes assigned to chr 7/7L/7S XB-GENEPAGE-5832502 is uncertain., but we are going to provisionally call it GSG1L2-like , or gsg1l2l following David's reasoning.
David Webb reports:
It's clearly a germ cell-specific gene 1-like paralog and in amphibians and reptiles it generally resides at SHISA7> UBE2S> RCVRN> RPL28< "GSG1L"> .
It is still present in platypus as GeneID: 114814554 at SHISA7> UBE2S> RCVRN> RPL28< "GSG1L"> FAM171E2>
whereas in therian mammals the gene is lost from this region: SHISA7> UBE2S> RPL28< TMEM238> TMEM190< IL11> FAM171E2>.
However, in placental mammals there's a GSG1L2 gene near their RCVRN gene so GSG1L2 may be orthologous to the chr 7 "GSG1L" gene in Xenopus.
Platypus has two RCVRN-like genes and these may reveal the change in the location of Xtr "GSG1L" to mammalian GSG1L2 but marsupials seem to lack this GSG1L2/ "GSG1L" gene so I can't fully trace the synteny evolution.
Human/mammalian GSG1L2 resides at GAS7> RCVRN> GLP2R< GSG1L2> DHRS7C> USP43< CFAPS2<