XB-FEAT-5871493
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itf54
This is the community wiki page for the gene itf54 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.
nomeclature updates
05MAY2026
Xenopus gene names was updated, changing from traf3ip1 ,TRAF3 interacting protein 1 to itf54, intraflagellar transport 54, following changes in the human ortholog.
summary for human ITF54 from NCBI
The protein encoded by this gene interacts with TNF receptor-associated factor 3, tethering it to cytoskeletal microtubules. The encoded protein is also an inhibitor of the innate type I IFN response. Defects in this gene are a cause of Senior-Loken syndrome 9. [provided by RefSeq, Mar 2017]