XB-FEAT-5954422

fcn3.2

This is the community wiki page for the gene fcn3.2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

summary for human FCN3 from NCBI

Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and two variants, each encoding a distinct isoform, have been identified. [provided by RefSeq, Jul 2008]

nomenclature updates

10DEC2025

Xenopus gene name changed from XB5954422, uncharacterized XB5954422 to fcn3.2, ficolin 3 gene 2 following orthogy and synteny analysis.