XB-FEAT-877260

rergl2

This is the community wiki page for the gene rergl2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

25APRIL2023 Xenopus gene name changed from rergl.2 (provisional) to rergl2 (provisional).

22MAY2023 REMOVED PROVISONAL DB TAGS AND SUFFIXES FROM GENE NAME AND SYMBOL.

synteny and orthology

25April2023

There are 3 'RERG' family genes annotated inv10 genome for Xenopus tropicalis:

1) rerg RAS like estrogen regulated growth inhibitor on chr3/3L. XB-GENEPAGE-489596

2) rergl RERG/RAS-like on Chr3/3L/3S XB-GENEPAGE-6037389

3) rergl2 RAS like estrogen regulated growth inhibitor like 2 (provisional) on Chr4/4L [XB-GENEPAGE-877260] where its is flanked by mrpl21, ighmbp2, syt12 ptdss2 downstream (the upstream the genes are uncharacterized)

Based on pattern of synteny, the rergl2 X. tropicalis gene (GeneID:100145332) is NOT the true ortholog of human RERG nor RERGL. It seems to be a Xenopus and possibly other amphibian species' gene is very similar to RERGL, so is named is provisionally here with the '2' suffix, assuming it is a unique rergl gene, but not a .2 as this is solely used for tandem duplications.