XB-FEAT-990243

pde9al

This is the community wiki page for the gene pde9al please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

orthology

25APRIL2023

this gene was previously unnamed.

Assessment by Xenbase using DIOPT/EggNogg tool matches the Xtrop protein to the PDE/phosphodiesterase group with homology groups with high confidence- matching ~3000 proteins from ~300 species, including many proteins/genes in mammals, reptiles, birds/chicken and fish.

We will provisionally rename based on the current Uniprot protein symbol, 'pde9a' . and the human gene name for PDE9A, ie phosphodiesterase 9A.

nomenclature change

25APRIL2023

Xenopus gene symbol/name changed from Putative ortholog of cGMP-specific 3',5'-cyclic phosphodiesterase 9A XB990243 to pde9a, phosphodiesterase 9A

03/03/2025 based on synteny patterns, the pde9a genes on chr 2 are supported as the true orthologs of PDE9A, so these chr 7 genes have been renamed pde9al.

protein

high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [Xenopus tropicalis]

NCBI Reference Sequence: XP_012822440.1

>XP_012822440.1 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [Xenopus tropicalis] MGSGASAHGQKTIYLDVDGKIQKVVFSQHSSPAEIKELLCASAGLPWQAAIILLDKKGTVVATDSTIPKN SKSSAYRIVSRSISPRPEKEDFFQNILSQVTEEFSRAFRVTEMKREVMERLAMLERRMEVEGLKAIDIDK CKNELKNLRDEMEKKTSRLSCPCRFYYSEDIKKLNPRRDVPTYPKYTLSSETIDALKKPTFDVWHWEYNE MLSCLEFMYHDLGLVREFNMNPITLKRWLLCIQENYRTNPFHNFRHCFCVTQMMYGMIHLCNLQEKMSLI ELGVLMTSAVCHDLDHPGYNNTYQINAHTELAIRYNDMSPLENHHCAVAFQILAQPENNIFANITPELFK QIRQSIIRLILATDMARHGEILESFKKVLPNFDFSNEDHVKTLQMVLIKCCDISNEVRPTKVAEPWVDCL LEEYFMQSDREKSEGLPVTPFMDRDKVTKPKAQIGFIKFVLIPMFESVMKLFPHIEEVMVLPLREARDHY EELMEIEEALAEVQQKKSATLSIGGKLQVSA