XB-FEAT-962122: Difference between revisions
imported>Xenbase gene generator No edit summary |
imported>Xenbase |
||
| (One intermediate revision by one other user not shown) | |||
| Line 1: | Line 1: | ||
=homer3= | =homer3= | ||
This is the community wiki page for the gene ''homer3'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''homer3'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=nomenclature changes= | |||
02/23/2015 Human name has changed for Entrez Gene: 9454. From homer homolog 3 (Drosophila) to homer scaffolding protein 3 | |||
03.12.18 | |||
Human name has changed for Entrez Gene: 9454. From homer scaffolding protein 3 to homer scaffold protein 3 | |||
=Summary from NCBI= | |||
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009] | |||
Latest revision as of 13:47, 13 March 2018
homer3
This is the community wiki page for the gene homer3 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
02/23/2015 Human name has changed for Entrez Gene: 9454. From homer homolog 3 (Drosophila) to homer scaffolding protein 3
03.12.18
Human name has changed for Entrez Gene: 9454. From homer scaffolding protein 3 to homer scaffold protein 3
Summary from NCBI
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]