XB-FEAT-962122

homer3

This is the community wiki page for the gene homer3 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

02/23/2015 Human name has changed for Entrez Gene: 9454. From homer homolog 3 (Drosophila) to homer scaffolding protein 3

03.12.18 Human name has changed for Entrez Gene: 9454. From homer scaffolding protein 3 to homer scaffold protein 3

Summary from NCBI

This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]