NSC-87877: Difference between revisions
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imported>Kevin Created page with "==Description== [[File:______|frame|right|_______ structure, photo from Sigma-Aldrich]] ==Genes Affected== ==Suppliers== *[http://www.xenbase.org/entry/ SORRYONLYALINKTOXENB..." |
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==Description== | ==Description== | ||
[[File: | "Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation." | ||
*-Tocris Product Description | |||
[[File:NSC-87877.png|frame|right|NSC-87877 structure, photo from PubChem]] | |||
==Genes Affected== | ==Genes Affected== | ||
SHP1/2 are synonyms for [http://www.xenbase.org/gene/showgene.do?method=display&geneId=487862& ptpn6] and [http://www.xenbase.org/gene/showgene.do?method=display&geneId=6054494 ptpn11] | |||
==Suppliers== | ==Suppliers== | ||
*[http://www. | *[http://www.tocris.com/dispprod.php?ItemId=5168#.VYmtxvlVhBc Tocris] | ||
*[https://www.caymanchem.com/app/template/Product.vm/catalog/14908 Cayman] | |||
*[http://www.scbt.com/datasheet-204139-nsc-87877.html Santa Cruz] | |||
==Usage Notes== | ==Usage Notes== | ||
==References== | ==References== | ||
*[https://pubchem.ncbi.nlm.nih.gov/ Pubchem] | *[https://pubchem.ncbi.nlm.nih.gov/compound/5459322 Pubchem] | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId= | *[http://www.xenbase.org/literature/article.do?method=display&articleId=38144 Qian 2008] | ||
*[http://www.xenbase.org/literature/article.do?method=display&articleId=36582 Langdon 2007] | |||
> | >Search for Xenbase articles containing a reference to NSC-87877 using [http://www.xenbase.org/cgi-bin/textpresso/xenopus/search textpresso] | ||
* | * | ||
*[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | *[[Small Molecules for Xenopus Research|Back To Small Molecules Home Page]] | ||
Latest revision as of 07:54, 25 June 2015
Description
"Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation."
- -Tocris Product Description
Genes Affected
SHP1/2 are synonyms for ptpn6 and ptpn11
Suppliers
Usage Notes
References
>Search for Xenbase articles containing a reference to NSC-87877 using textpresso