NSC-87877

Description

"Potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP) (IC50 values are 0.318, 0.355, 1.691, 7.745, 65.617, 84.473 and 150.930 μM for shp2, shp1, PTP1B, HePTP, DEP1, CD45 and LAR respectively). Inhibits EGF-induced Erk1/2 activation in HEK293 cells and significantly reduces MDA-MB-468 cell viability/proliferation."

• -Tocris Product Description

NSC-87877 structure, photo from PubChem

Genes Affected

SHP1/2 are synonyms for ptpn6 and ptpn11

Suppliers

• Tocris
• Cayman
• Santa Cruz

References

• Pubchem
• Qian 2008
• Langdon 2007

>Search for Xenbase articles containing a reference to NSC-87877 using textpresso

• Back To Small Molecules Home Page