XB-FEAT-486640: Difference between revisions
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=bcl11a= | =bcl11a= | ||
This is the community wiki page for the gene ''bcl11a'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | This is the community wiki page for the gene ''bcl11a'' please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase | ||
=nomenclature changes= | |||
12/18/2017 | |||
Human name has changed for Entrez Gene: 53335. From B-cell CLL/lymphoma 11A to B cell CLL/lymphoma 11A | |||
=NCBI Summary= | |||
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | |||
=Nomenclature updates= | |||
11/06/2018 | |||
Human name has changed for Entrez Gene: 53335. From B cell CLL/lymphoma 11A to BCL11A, BAF complex component | |||
Latest revision as of 13:15, 6 November 2018
bcl11a
This is the community wiki page for the gene bcl11a please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
nomenclature changes
12/18/2017
Human name has changed for Entrez Gene: 53335. From B-cell CLL/lymphoma 11A to B cell CLL/lymphoma 11A
NCBI Summary
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Nomenclature updates
11/06/2018 Human name has changed for Entrez Gene: 53335. From B cell CLL/lymphoma 11A to BCL11A, BAF complex component