XB-FEAT-486640

bcl11a

This is the community wiki page for the gene bcl11a please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

12/18/2017

Human name has changed for Entrez Gene: 53335. From B-cell CLL/lymphoma 11A to B cell CLL/lymphoma 11A

NCBI Summary

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Nomenclature updates

11/06/2018 Human name has changed for Entrez Gene: 53335. From B cell CLL/lymphoma 11A to BCL11A, BAF complex component