XB-FEAT-1006127: Difference between revisions
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=notes on tdg gene expression and function= | =notes on tdg gene expression and function= | ||
source: talk by Christof Niehrs July 30th, 2017, EAC, Rennes, France. | source: talk by Christof Niehrs July 30th, 2017, EAC, Rennes, France. | ||
=summary from NCBI= | |||
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008] | |||
Latest revision as of 00:42, 30 June 2017
tdg
This is the community wiki page for the gene tdg please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase
notes on tdg gene expression and function
source: talk by Christof Niehrs July 30th, 2017, EAC, Rennes, France.
summary from NCBI
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]