XB-FEAT-1006127

tdg

This is the community wiki page for the gene tdg please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

notes on tdg gene expression and function

source: talk by Christof Niehrs July 30th, 2017, EAC, Rennes, France.

summary from NCBI

The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]