AZD1480

Description

Inhibits the Jak Stat pathway. AZD1480 is a novel ATP-competitive JAK2 inhibitor with IC50 of 0.26 nM in a cell-free assay, selectivity against JAK3 and Tyk2, and to a smaller extent against JAK1. Phase 1.

Structure of AZD1479, photo from Selleck Chemical

• • Genes Affected
  • jak1
  • jak2

Suppliers

• PubChem
• Selleck Chemicals
• Santa Cruz

References

• Hyakutake et al., 2015
• Bergmann et al., 2010
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