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Barasertib specifically binds to and inhibits Aurora kinase B, which results in the disruption of spindle checkpoint functions and chromosome alignment and, so, the disruption of chromosome segregation and cytokinesis.

In XB-ART-54542, BAPTA-AM used to inhibit migration of the leading edge mesoderm in gastrulation.

Barasertib structure, image from PubChem

Alternative names

  • AZD1152
  • UNII-16XC2U7W8N


Usage Notes


> 8 Xenbase articles contain a reference to Barasertib or AZD1152 according to textpresso