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MAPK/JNK inhibitor.

"A novel and selective inhibitor of c-Jun N-terminal kinase (JNK) SP600125 is an anthrapyrazolone inhibitor of JNK that competes with ATP to inhibit the phosphorylation of c-Jun. It prevents the activation of inflammatory genes such as COX-2, IL-2 IFN-γ and TNF-α.8,9 It prevents the activation of JNK after brain ischemia and may be effective in treatment of ischemic stroke.10"

  • -Sigma Product Description
SP600125 structure, photo from Sigma-Aldrich

Genes Affected

mapk8 mapk1


Usage Notes


>28 Xenbase articles contain a reference to SP600125 according to textpresso