XB-FEAT-1000518

neil2

This is the community wiki page for the gene neil2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

gene expression notes

neil2 is expressed in stage 10 at very low levels, and is barely visible in ISH, thus there are no published or available images of expression for this gene. Christoph Niehrs is working on this gene, and has conducted numerous MO knockdown experiments.

summary from NCBI

This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]