XB-FEAT-22064966

fgl1l

This is the community wiki page for the gene fgl1l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

Notes on synteny/orthology

02JULY2020

from David Webb, NCBI refSeq project:

fgl1l is another fibrinogen 1-like gene that appears to have been lost in mammals but its evolutionary history is potentially more complicated and so I'm not comfortable asserting orthology between the genes in amphibians, teleosts, and birds.

This gene regularly resides at KATNBL1> EMC7> FGL1-like> CHRM5< AVEN> RYR3< at least as far back as gnathostomes.

However, in zebrafish the inferred ortholog (GeneID: 571819, ZDB-GENE-081022-162) shares synteny only with CHRM5a while the inferred ortholog in X. tropicalis (GeneID: 100490490, XB-GENE-22064967) and other amphibians shares synteny only in the other direction KATNBL1> EMC7> FGL1-like>.

The inferred ortholog in chicken (GeneID: 112532477) retains the ancestral synteny at KATNBL1> EMC7> FGL1-like> CHRM5< AVEN> RYR3<.

Mammals also retain the ancestral synteny, except that this fibrinogen 1-like gene (fgl1l) has been lost -there are no traces of transcription or a disrupted CDS of this gene in mammals.