XB-FEAT-479180

nbl1

This is the community wiki page for the gene nbl1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature issues

05.14.2018

Human name has changed for Entrez Gene: 4681. From neuroblastoma 1, DAN family BMP antagonist to NBL1, DAN family BMP antagonist

summary from NCBI

This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]