XB-FEAT-485053

h2az1

This is the community wiki page for the gene h2az1 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

08.23.2019

Human symbol has changed for genepage ID: 485053 From h2afz to h2az1

Human symbol has changed for Entrez Gene: 3015. From H2AFZ to H2AZ1

Human name has changed for Entrez Gene: 3015. From H2A histone family member Z to H2A.Z variant histone 1

gene marker

h2az1 is considered a good marker for multiciliated cells. See XB-ART-59700 Lee et al 2023, PubMed ID: 37027470

Summary from NCBI

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. Studies in mice have shown that this particular histone is required for embryonic development and indicate that lack of functional histone H2A leads to embryonic lethality. [provided by RefSeq, Jul 2008]