XB-FEAT-486324

cltrn

This is the community wiki page for the gene cltrn please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

For a laevis probe use OpenBiosystems CloneID 4031619

NCBI Summary

This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013].

nomenclature changes

12/18/2017 Human symbol has changed for genepage ID: 486324 From tmem27 to cltrn

Human symbol has changed for Entrez Gene: 57393. From TMEM27 to CLTRN

Human name has changed for Entrez Gene: 57393. From transmembrane protein 27 to collectrin, amino acid transport regulator