XB-FEAT-489247

nedd4l

This is the community wiki page for the gene nedd4l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

05.13.19

Human name has changed for Entrez Gene: 23327. From neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase to NEDD4 like E3 ubiquitin protein ligase

Summary from NCBI for human NEDD4L

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]