XB-FEAT-492511

kit

This is the community wiki page for the gene kit please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

04/22/ 2016 Human name has changed for Entrez Gene: 3815. From v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog to KIT proto-oncogene receptor tyrosine kinase

gene expression notes

kit expression is restricted to MCC ( multi-ciliated cells)

Kodjabachian labs' research has shown that alterantions in the scf/kit pathway disrupts the pattern of MCC distribution, mostly causing a delay in the intercalation within the outer epidermal layer . The MCC's spend more time wandering between the inner and outer layers, instead of directly migrating to the outer alyer and intercalting with the other secretory cells.