XB-FEAT-493519

axin2l

This is the community wiki page for the gene axin2l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

04/19/2023

gene name changed from axin 2 (conductin, axil) to axin 2.

04/20/2023

Following review of gene orthology (via DIOPT and synteny, see below). NCBI calls LOC116406464 (on Chr10, NSXETG00000013607) axin2, and synteny confirms LOC116406464 is the true ortholog of human AXIN2.

the gene name changed from axin 2 to axin 2 like

the gene symbols changed from axin2 to axin2l

Synteny

True axin2 orthologs in Xenopus are on chr10/9_10.L, matching the syntenic pattern in mamals/human.

Xtropchr10: slc16a6> amz2< gna13< LOC|rgs9> LOC116406464|AXIN2< cep112< apoh< prkca>

Xla.9_10L: amz2.L< gna13.L< rgs11.L> LOC108701205|axin-2< LOC108701206|cep112< apoh.L< prkca.L>

Human.Chr17: [enhancers] GNA13< [LOCs| ncRNA/enhancers] RGS9> [enhancers] AXIN2< CEP112

A new Xenbase gene page is being created for axin2 genes.

The 2nd AXIN2 gene, provisionally called axin 2 like/axin2l in Xenopus are all found on Chr7/7L.

Xtr.chr7: aqp10< sult2a1> itprip> XB5850668> fam83e< axin2> pitpnc1l< cacng8< cacng7< prkcg LOC< myadm>

Xla.7L rv: rps9.L> sult2a1.L> XB986081.L|sult2b1< LOC108695915|sult2b1-like< XB5850668.L< LOC108695914|sult2b1[like2]< LOC108696783|unch> fam83e.L< axin2.L> pitpnc1l.L< LOC108696779< cacng8.L< cacng7.L< prkcg.L LOC108696776|PRKCG.L< myadm.L>