XB-FEAT-5769296

h4c12

This is the community wiki page for the gene h4c12 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

08.23.2019 Human symbol has changed for genepage ID: 5769296 From hist1h4k to h4c12

Human symbol has changed for Entrez Gene: 8362. From HIST1H4K to H4C12

Human name has changed for Entrez Gene: 8362. From histone cluster 1 H4 family member k to H4 clustered histone 12

Summary for human H4C12 from NCBI

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]