XB-FEAT-5835883

acd

This is the community wiki page for the gene acd please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

Summary for Human ACD from NCBI

This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]

synonyms

In mouse, this gene is known as adrenocortical dysplasia, and thus the origin of the gene symbol acd.

nomenclature changes

04/14/2023

Following orthology and synteny analysis, the gene name & symbol was changed from XB5835883 to adc, ACD shelterin complex subunit and telomerase recruitment factor.

Although synteny with mammals is not maintained, the gene is in a conserved gene pattern in other amphibians.

Human/MOUSE/RAT: CTCF> CARMIL2> ACD< PARD6A> ENKD1<

compared with

Human chr6: TUBB2B< [ELEMENTS] LOC100422781 [ENHANCERS/SILENCER ELEMENTS, sharpr reg region 12113] PSMG4> SLC22A23<

Amphibians:

Xtropicalis Chr6: slc22a23> psmg4< XB5835883> bphl< tubb2b> serpinb4< serpinb11< ecl3<

Xlaevis Chr6.L: slc22a23.L> psmg4.L< XB5835883.L> bphl.L< tubb2b.L> serpinb4.L< ecl3.L<

Xlaevis Chr6.S: slc22a23.S> psmg4.S< XB5835883.S> tubb2b.S>

Nanorana parkeri: BPHL> ACD< PSMG4> SLC22A23<

gene identity is also strongly support by DIOPT analsyis, comparing protein to homology groups in DIOPT/EggNog.