XB-FEAT-5872748

selenop2l

This is the community wiki page for the gene selenop2l please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

nomenclature changes

09/12/2017

named changed (XB-GENE-5872749) from selenoprotein P, plasma, 1 to selenoprotein P2-like

symbol changed (XB-GENE-5872749) from unnamed to selenop2l    

correspondance from NIH

from Bhanu Rajput, Ph. D., Staff Scientist, Reference Sequence Project, NCBI/NLM/NIH

3.  selenop (GeneID:100379942, XB-GENE-5866766) and 'unnamed' (GeneID:448755, XB-GENE-5872749) are paralogous genes on chromosome 1 and 4, respectively.

selenop encodes a selenoprotein with mutliple selenocysteine (Sec) residues (18), similar to SELENOP orthologs in mammals.

'unnamed' has exon structure similar to selenop gene and encodes a protein with high sequence similarity to proteins referred to as selenoprotein Pb or selenoprotein Pb-like (PMIDs:22479358, 11168591), but it is NOT a selenoprotein.

Some selenoproteinPb proteins contain a single Sec residue (e.g., zebrafish NP_840083.2 and chicken NP_001335698.1), but in frog, Sec is replaced by cysteine. For this reason, naming this locus is hard because it represents a cysteine-containing homolog of selenoprotein Pb protein family.

To comply with Gladyshev et al.'s recommendation for naming paralogs (PMID:27645994, in table 3, SELENOP2 is recommended symbol for synonym SELPb), I would like to suggest the following nomenclature update for selenop and 'unnamed', but am open for the naming of the latter:   current                       symbol        name selenop (XB-GENE-5866766) >   selenop1      selenoprotein P1 

unnamed (XB-GENE-5872749) >   selenop2l     selenoprotein P2-like

ACTION BY XENBASE: 09/12/17 Changed GENE SYMBOLS AND NAMES AS REQUESTED

XB-GENE-5866766 FROM selenop TO   selenop1, selenoprotein P1

XB-GENE-5872749 FROM unnamed TO  selenop2l,  selenoprotein P2-like