XB-FEAT-5936415

ggh.2

This is the community wiki page for the gene ggh.2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

9.13/2021

the name of this gene was changed, adding "gene 2" as a suffix, to clarify that there are two ggh gene in Xenopus. (see below)

synteny pattern

Note that there are 2 ggh" genes in Xenopus: ggh) is on Chromosome 6, and ggh.2 on chromosome 3.

where ggh seems to be the true ortholog of Human GGH, as the synteny pattern in largely conserved through evolutionary time.

Xtr v10: Chr6: nkain3> ... ... mcmdc2< ... ggh< ... ttpa< ... [prov] zbed5> ...

Xla. v10 Chr6.L: LOC108718582.L> ... mcmdc2.L< ... ggh.L< ... ttpa.L< ... ythdf3.L> ...

Human: NKAIN3> ... LOC3> ... SRPK2P< ... LOC#> ... GGH ... TTPA...

COMPARED with THE REGION ON CHROMOSOME 3 which is not very well annotated.

IN X. TROPICALIS, THE 2ND GENE DOES NOT SEEM TO HAVE A DIRECT EASY TO IDENTIFY ORTHOLOG.

Xtr. v10 Chr 3: pleha2 ... [2 x unamed loc] tm2d2 ... adam9 ... [Xtrre loc]. ggh.2 ... [ 3 more unnamed Xtr loc]

Xlaevis v10 chr3.L: (reverse order): LOC108710634 ggh.2.L < ... adam9. L< tm2d2.L. ... htra4.L < plekha2.L

Human: PLEHA2 ... HTRA4 ... TM2D2 ...ADAM9 ... ADAM32 ... RPL3P10 LOC#