XB-FEAT-940948

srd5a2

This is the community wiki page for the gene srd5a2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

nomenclature changes

7.26.2021

Xenopus name changed from "steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)" to "steroid 5 alpha-reductase 2" following human as per Xenopus naming guidelines.

the Xenopus gene symbol is unchanged.

summary from NCBI for human SRD5A2

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]