XB-FEAT-962773

nek2

This is the community wiki page for the gene nek2 please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

notes on gene function

source: The NIMA-like kinase Nek2 is a key switch balancing cilia biogenesis and resorption in the development of left-right asymmetry. By S. Joseph Endicott, Basudha Basu, Mustafa Khokha, Martina Brueckner. Development 2015 142: 4068-4079; doi: 10.1242/dev.126953

"Nek2 is a member of the NIMA (never in mitosis gene a) family of serine-threonine kinases, highly conserved across vertebrates, with roles in cell cycle and centrosome biology (Fry et al., 2012). Moreover, nek2 is expressed in the developing Xenopus LRO and kidney, tissues where cilia are essential for function (Fakhro et al., 2011)."

"In addition to facilitating centriole splitting on mitotic entry, Nek2 is also required for timely disassembly of the cilium in mammalian cultured cells, and NIMA family kinases have been implicated in cilia resorption in species as divergent from vertebrates as Tetrahymena and Chlamydomonas (Mahjoub et al., 2004; Wloga et al., 2006). "

"At the onset of mitosis, the nuclear envelope (NE) must be broken down, beginning with the partial disassembly of the nuclear pore complexes (NPCs). Nek2 (along with Nek6 and Nek7) plays a role in this process by phosphorylating a regulator of NPC stability, Nup98, at four of its 13 phosphorylation sites."