XB-FEAT-984424

kl

This is the community wiki page for the gene kl please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase

summary for human KL/klotho from NCBI

This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008]