XB-FEAT-984500

ostn

This is the community wiki page for the gene ostn please feel free to add any information that is relevant to this gene that is not already captured elsewhere in Xenbase.

gene/protein function

Source: Devotta et al 2023:https://doi.org/10.7554/eLife.84036

Osteocrin/musclin (Ostn) was originally identified in a screen for secreted signaling peptides in bone (Thomas et al., 2003) and skeletal muscle (Nishizawa et al., 2004).

Ostn binds Npr3 specifically and with high affinity, competing with other ligands for binding (Kita et al., 2009; Moffatt and Thomas, 2009).