Small Molecules for Xenopus Research: Difference between revisions

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==Notice to our users==
Please help us to improve this small molecules wiki and our other wikis by registering for a wiki account through our normal feedback email.
==Important small molecule references==
==Important small molecule references==
*[http://www.xenbase.org/literature/article.do?method=display&articleId=35021 Database of Small Molecules by Feldman and Hogue 2006]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=35021 Database of Small Molecules by Feldman and Hogue 2006] at [https://pubchem.ncbi.nlm.nih.gov/ PubChem]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=47903 Wnt/Notch by Myers and Krieg 2014]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=47903 Wnt/Notch by Myers and Krieg 2014]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=970 Ubiquitin-proteasome by Salic and King 2005]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=970 Ubiquitin-proteasome by Salic and King 2005]
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==Alphabetical List of Small Molecules With Literature References==
==Alphabetical List of Small Molecules With Literature References==


*[[1,3-Dicyclohexylurea]]
*[[11-cis retinal]]
*[[11-cis retinal]]
*[[18alpha-glycyrretinic acid]]
*[[18alpha-glycyrrhetinic acid]]
*[[2'-deoxyadenosine]]
*[[2-APB]]
*[[2-Deoxyglucose]]
*[[3,3,5-triiodothyronine (T3)]]
*[[3,3,5-triiodothyronine (T3)]]
*[[5HT (seratonin)]]
*[[5HT (seratonin)]]
*[[8-Pcpt-2-O-Me-cAMP-AM]]
*[[activin]]
*[[activin]]
*[[Adenosine, periodate oxidized]]
*[[AG1296]]
*[[AG1296]]
*[[AG1879]]
*[[AG1879]]
*[[AGN193109]]
*[[AGN193109]]
*[[alpha-amanitin]]
*[[alpha-amanitin]]
*[[Alisertib]]
*[[anandamide]]
*[[anandamide]]
*[[AP-III-a4]]
*[[apelin]]
*[[apelin]]
*[[aphidicolin]]
*[[aphidicolin]]
*[[Aroclor 1254]]
*[[Atrazine]]
*[[AZD1480]]
*[[AZD1480]]
*[[Bafilomycin A1]]
*[[BAPTA-AM]]
*[[BAPTA-AM]]
*[[Barasertib]]
*[[Benzaldehyde, 3-allyl-2-(2-(diethylamino)ethoxy)-(DEAB)]]
*[[beta-xyloside]]
*[[beta-xyloside]]
*[[blebbistatin]]
*[[BMS-453]]
*[[Brefeldin A (BFA)]]
*[[bumetanide]]
*[[bumetanide]]
*[[calcium ionophore]]
*[[calcium ionophore]]
*[[canertinib]]
*[[CGP54626 ]]
*[[CGP54626 ]]
*[[Chelerythrine]]
*[[Chelerythrine]]
*[[chenodeoxycholic acid]]
*[[chlorpromazine]]
*[[chymostatin ]]
*[[chymostatin ]]
*[[Citral]]
*[[Colcemide]]
*[[concanamycin]]
*[[concanamycin]]
*[[CP-91149]]
*[[cycloheximide]]
*[[cycloheximide]]
*[[cyclopamine]]
*[[cyclopamine]]
*[[Cyclosporin A]]
*[[Cytochalasin B]]
*[[Cytochalasin B]]
*[[cytochalasin D]]
*[[D-AP5]]
*[[D-NAME]]
*[[deltamethrin]]
*[[dexamethosone]]
*[[dexamethosone]]
*[[DHT(dihydrotestosterone)]]
*[[DHT(dihydrotestosterone)]]
*[[diazepam]]
*[[Difopein]]
*[[Diphenyleneiodonium Chloride]]
*[[DMH-1]]
*[[Dorsomorphin]]
*[[DRB]]
*[[Ex-527]]
*[[Ex-527]]
*[[finasteride]]
*[[folic acid]]
*[[forskolin]]
*[[forskolin]]
*[[fusicoccin]]
*[[fusicoccin]]
*[[gallein]]
*[[GANT 61]]
*[[gentamycin]]
*[[gentamycin]]
*[[GSK3-inhibitor IX (BIO)]]
*[[GM6001]]
*[[GM6001]]
*[[H-89 Dihydrochloride]]
*[[heptanol]]
*[[heptanol]]
*[[herbimycin A]]
*[[herbimycin A]]
*[[Hh-Ag1.8]]
*[[Hydroxyurea]]
*[[IBMX]]
*[[IBMX]]
*[[Iodoacetic acid]]
*[[jasplakinolide]]
*[[6-B345TTQ]]
*[[Ketamine]]
*[[KT 5720]]
*[[KT 5720]]
*[[lansoprazol]]
*[[L-NAME]]
*[[lansoprazole]]
*[[latrunculin A]]
*[[latrunculin B]]
*[[LDN-193189]]
*[[Leflunomide]]
*[[leucovorin]]
*[[LiCl]]
*[[LiCl]]
*[[Lovastatin]]
*[[LY294002]]
*[[m-3M3FBS]]
*[[methotrexate (MTX)]]
*[[metronidazole]]
*[[Mg132]]
*[[Mg132]]
*[[mHip]]
*[[MK-2206]]
*[[MMP-2 inhibitor II]]
*[[MMP-2 inhibitor II]]
*[[MS-275]]
*[[Mubritinib]]
*[[nicorandil]]
*[[nicorandil]]
*[[Nicotinamide]]
*[[Nicotinic acid]]
*[[nifedipine]]
*[[nifedipine]]
*[[nocodazole]]
*[[nocodazole]]
*[[NSC-87877]]
*[[NSC-87877]]
*[[o-phenanthroline]]
*[[o-phenanthroline]]
*[[okadaic acid]]
*[[olomoucine]]
*[[olomoucine]]
*[[ouabain]]
*[[ouabain]]
*[[Olygomycin]]
*[[PD173074]]
*[[PD-407824]]
*[[p-MPPI]]
*[[p-MPPI]]
*[[taxol|Paclitaxel]]
*[[phaclofen]]
*[[phaclofen]]
*[[phenylthiourea|phenylthiourea (PTU)]]
*[[Picropodophyllin]]
*[[PMA]]
*[[PMA]]
*[[PP2]]
*[[PP2]]
*[[primaquin]]
*[[primaquine]]
*[[propythiouracil]]
*[[Progesterone]]
*[[propylthiouracil]]
*[[psoralen]]
*[[pyrimethamine]]
*[[quinpirole]]
*[[rac1 inhibitor]]
*[[rapamycin]]
*[[retinoic acid]]
*[[retinoic acid]]
*[[Retinol]]
*[[RO-3306]]
*[[RS67333]]
*[[RS67333]]
*[[RU486]]
*[[RU486]]
*[[SAHA]]
*[[SB 203580]]
*[[SB 203580]]
*[[SB431542]]
*[[SB-505124]]
*[[SCH28080]]
*[[SNAP]]
*[[sodium nitroprusside]]
*[[sodium nitroprusside]]
*[[sodium perchlorate]]
*[[SP600125 ]]
*[[SP600125 ]]
*[[SU5402]]
*[[SU5402]]
*[[SU6656]]
*[[SU6656]]
*[[Suramin]]
*[[Suramin]]
*[[tautomycin]]
*[[taxol]]
*[[thyroxine (T4)]]
*[[thyroxine (T4)]]
*[[Torin 2]]
*[[Trichostatin A]]
*[[trimetrexate]]
*[[Triptolide]]
*[[TTNPB]]
*[[TTNPB]]
*[[Tubercidin]]
*[[tunicamycin]]
*[[tunicamycin]]
*[[Tyrphostin AG 1478]]
*[[U73122]]
*[[Y27632]]
*[[Y27632]]
*[[ZM 447439]]
*[[ZM 447439]]


==List of Molecules Affecting Specific Pathways==
The Following are in need of standardization and curation
*[[AM251]]
*[[AM281]]
*[[AP1510]]
*[[AR-A014418]]
*[[BHQ]]
*[[b-aminoproprionitrile]]
*[[beclomethasone]]
*[[Butyrate]]
*[[calcicludine]]
*[[Calyculin A]]
*[[celastrol]]
*[[celecoxib]]
*[[chromanol 293B]]
*[[chlorate]]
*[[cytochalasin D]]
*[[colchicine]]
*[[dimethyloxallyl glycine (DMOG)]]
*[[diclofenac]]
*[[etoposide]]
*[[IWR1]]
*[[GW843682X]]
*[[leptomycin B]]
*[[LY320135]]
*[[methylcellulose (MC)]]
*[[methimazole]]
*[[MBCD or MBetaCD]]
*[[MS222]]
*[[nicardipine]]
*[[Nu6102]]
*[[purmorphamine]]
*[[Pyrazoleanthrone]]
*[[R(+)BayK 8644]]
*[[RHC80267]]
*[[RL-3]]
*[[SAG]]
*[[SB-431542]]
*[[TG003]]
*[[Thapsigargin]]
*[[U0126]]
*[[ursodeoxycholic acid]]
*[[valproic acid (VPA)]]
*[[Echinomycin]]
*[[Gö 6983]]
*[[phenylhydrazine]]
*[[ω-conotoxin–GVIA]]
*[[flunarizine]]
*[[tetrodotoxin]]
*[[veratridine]]
*[[NBI-27914]]
 
==Small Molecules Affecting Pathways==
===cAMP===
===cAMP===
[[IBMX]]
*[[IBMX]]
*[[RU486]]
 
===CDK/Cyclins===
*[[olomoucine]]
*[[RO-3306]]
*[[R-roscovitine]]
 
===ERK/MAPK===
===ERK/MAPK===
*[[U0126]]
===Folic Acid===
*[[Methotrexate (MTX)]]
===JAK/STAT===
===JAK/STAT===
*[[AZD1480]]
*[[AZD1480]]
===JNK===
===JNK===
[[SP600125]]
*[[SP600125]]
*[[Pyrazoleanthrone]]
 
===Nitric Oxide===
*[[sodium nitroprusside]]


===PDGF===
===PDGF===
*[[AG1296]]
*[[AG1296]]
*[[AP1510]]
===Retinoic Acid===
===Retinoic Acid===
*[[AGN193109]]
*[[AGN193109]]
*[[Citral]]
*[[retinoic acid]]
*[[retinoic acid]]
*[[Retinol]]
*[[TTNPB]]
*[[TTNPB]]
*[[BMS-453]]
===Shh===
===Shh===
*[[cyclopamine]]
*[[cyclopamine]]
*[[mHip]]
*[[purmorphamine]]
*[[Hh-Ag1.8]]
*[[Vismodegib]]
 
===TGF-beta/BMP===
===TGF-beta/BMP===
*[[SB-431542]]
*[[SB505124]]
===Thyroid Signaling===
*[[NH-3]]
===Wnt===
===Wnt===
*[[LiCl]]
*[[LiCl]]
 
*[[GSK3-inhibitor IX (BIO)]]
*[[IWR1]]


===Epigenetics===
===Epigenetics===
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*[[GM6001|GM6001 (MMP inhibitor)]]
*[[GM6001|GM6001 (MMP inhibitor)]]
*[[o-phenanthroline|o-phenanthroline(MMP inhibitor)]]
*[[o-phenanthroline|o-phenanthroline(MMP inhibitor)]]
*[[BB-94|BB-94 MMP inhibitor]]
*[[GI254023X| GI254023X MMP10 inhibitor]]


==Small Molecules affecting Biological Functions & Processes==
===Angiogenesis===
*[[dimethyloxallyl glycine (DMOG)]]
*[[herbimycin A]]
*[[Suramin]]


===Apoptosis===
*[[cycloheximide]]
*[[alpha-amanitin]]
*[[Cyclosporin A]]
*[[2,2ʹ-Methylenebis(1,3-cyclohexanedione)]]
*[[NS3694]]


===Autophagy===
*[[LY-294002]]


===Calcium Signaling===
*[[nifedipine]]
*[[R(+)BayK 8644]]
*[[nicardipine]]
*[[deltamethrin]]
*[[BHQ]]
*[[Thapsigargin]]


===Circadian Rhythm===
*[[quinpirole]]


==Small Molecules by Biological Function==
===Angiogenesis===
*[[herbimycin A]]
===Autophagy===
*[[LY-294002]]
===Cytoskeletal Inhibitors===
===Cytoskeletal Inhibitors===
*[[Cytochalasin B]]
*[[Cytochalasin B]]
*[[cytochalasin D]]
*[[Colcemide]]
*[[Colchicine]]
*[[jasplakinolide]] is an activator
*[[latrunculin B]]
*[[taxol]]
*[[taxol|Paclitaxel]]
===Cell Cycle, including mitosis===
*[[Colcemide]]
*[[Hydroxyurea]]
*[[olomoucine]]
*[[PD-407824]]
===Cell migration, including specific cell lineage removal===
*[[Clodronate]]
===Cilia===
*[[methylcellulose (MC)]]
===DNA Damage/Repair===
*[[etoposide]]
*[[Hydroxyurea]]
===DNA Synthesis===
*[[Calyculin A]]
===DNA mutagenic compounds===
*[[ENU or N-nitroso-N-ethylurea]] 100mM Sigma N3385


===Growth Cone, Filopodia, and other Cytoskeletal projections===
===Growth Cone, Filopodia, and other Cytoskeletal projections===
*[[PP2]]
*[[PP2]]
*[[SU6656]]
*[[SU6656]]
*[[cytochalasin D]] 0.1 uM Sigma
*[[latrunculin B]] 30nM Sigma
*[[colchicine]] 12.5uM Sigma
*[[nocodazole]] 0.1uM Sigma
*[[RHC80267]]
===Hatching===
*[[ouabain]]
===Left-Right Patterning===
*[[methylcellulose (MC)]]


===Metamorphosis===
===Metamorphosis===
*[[3,3,5-triiodothyronine (T3)]]
*[[3,3,5-triiodothyronine (T3)]]
*[[methimazole]]
*[[propylthiouracil]]
*[[thyroxine (T4)]]
*[[thyroxine (T4)]]


===Neurotransmission===
*[[diazepam]]
*[[p-MPPI]]
*[[phaclofen]]
*[[RS67333]]
*[[deltamethrin]]


===Protein Recycling===
*[[primaquine]]


==Drugs by Gene Class==


===Channels, including ATPases===
*[[ouabain]]
*[[AM251]]
*[[AM281]]
*[[LY320135]]
*[[bafilomycin A1]]


===G Protein Receptors===
*[[purmorphamine]]
===Kinases===
*[[KT 5720]]
*[[olomoucine]]
*[[PD-407824]]
*[[SB 203580]]
*[[Y27632]]
*[[ZM 447439]]


===Phosphatases===
*[[Cyclosporin A]]
*[[deltamethrin]]
*[[okadaic acid]]
*[[tautomycin]]
*[[Calyculin A]]


===Small Molecules Studied in Oocytes Found Via Textpresso===
===Small GTPases===
 
 
===Protein Synthesis===
*[[anisomycin]] 40uM Sigma
*[[cycloheximide]] 40uM
 
===Retinoids===
*[[TTNPB]] Sigma
 
==Textpresso Small Molecules to Research==
*[http://www.xenbase.org/literature/article.do?method=display&articleId=43038 importazole inhibits importin]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=42068 M119]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=42068 M119]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=42068 GBG or GBetaGamma or G Protein Beta Gamma]
*[http://www.xenbase.org/literature/article.do?method=display&articleId=42068 GBG or GBetaGamma or G Protein Beta Gamma]
*[[LY-294002| LY-294002 inhibits PI3K and autophagy]]
*[[LY-294002| LY-294002 inhibits PI3K and autophagy]]


===Textpresso Small Molecules to Research===
==Models of Anemia==
*[http://www.xenbase.org/literature/article.do?method=display&articleId=43038 importazole inhibits importin]
*[[Phenylhydrazine]]
==Environmental toxins==
*[[Cis-bifenthrin (cis-BF)]]
*[[Graphine (GO)]]
*[[4-methylcyclohexane methanol (MCHM)]]
*[[4-octylphenol (OP)]]
*[[metamifop]]

Latest revision as of 07:21, 16 May 2023

Notice to our users

Please help us to improve this small molecules wiki and our other wikis by registering for a wiki account through our normal feedback email.

Important small molecule references

Alphabetical List of Small Molecules With Literature References

The Following are in need of standardization and curation

Small Molecules Affecting Pathways

cAMP

CDK/Cyclins

ERK/MAPK

Folic Acid

JAK/STAT

JNK

Nitric Oxide

PDGF

Retinoic Acid

Shh

TGF-beta/BMP

Thyroid Signaling

Wnt

Epigenetics

Protease Inhibitors

Small Molecules affecting Biological Functions & Processes

Angiogenesis

Apoptosis

Autophagy

Calcium Signaling

Circadian Rhythm

Cytoskeletal Inhibitors

Cell Cycle, including mitosis

Cell migration, including specific cell lineage removal

Cilia

DNA Damage/Repair

DNA Synthesis

DNA mutagenic compounds


Growth Cone, Filopodia, and other Cytoskeletal projections

Hatching

Left-Right Patterning

Metamorphosis

Neurotransmission

Protein Recycling

Drugs by Gene Class

Channels, including ATPases

G Protein Receptors

Kinases

Phosphatases

Small GTPases

Protein Synthesis

Retinoids

Textpresso Small Molecules to Research

Models of Anemia

Environmental toxins

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